Does your dog have osteoarthritis?

We are seeking dogs over 7 years of age with clinical signs of osteoarthritis to be involved in a clinical trial further evaluating a drug used for osteoarthritis management in dogs.

There is a high unmet medical need for therapies for osteoarthritis that improve pain and lameness and delay the disease's progression. There are strong similarities between osteoarthritis in dogs and people.  Consequently, any advance in treating osteoarthritis in dogs may be of interest for osteoarthritis treatment in humans.

Pentosan Polysulfate Sodium (PPS)  is a drug that has been used for over 20 years to help dogs suffering from osteoarthritis. Short term (1 to 3 months) results show that PPS reduces pain and lameness and improves joint health in dogs. Our study aims to assess if those positive effects are long-lasting in dog using state-of-the-art equipment, such as Magnetic Resonance Imaging or MRI, to evaluate the impact of inside the osteoarthritic joint. In addition, we will use Canine Gait analysing and lameness detection utilising a pressure-sensitive walkway (GAIT 4Dog). The study results will help establish objective research evidence that could be used to advance clinical development of PPS as a potential treatment for osteoarthritis in humans.

Your dog will need to have a physical examination, a blood sample taken, and X-rays of the affected joints taken. Eligible dogs receive a free health check, haematology, biochemistry and radiographs, valued at $1100. If eligible, your pet will enter a 6-month long clinical study. During that time, your pet will need to come to the U-Vet Hospital for 8 visits, including weekly drug injections for 6 weeks and 3 MRI imaging studies to evaluate the progression of the osteoarthritis. Some dogs will be in a placebo group. Weekly owner-based pain/welfare questionnaires will help us detect any signs of pain and provide those patients with rescue analgesia. In addition, at the end of the study, those dogs will receive free Pentosan treatment for six months

Conditions Apply

Dogs must be over 7 years of age with clinical signs of osteoarthritis and weigh between 15 and 30 kg. Dogs can be male or female and must be desexed.

Referring veterinarians will receive all findings from tests. If tests indicate other diseases, your referring vet will be informed. We reserve the right to end this offer at any time if information changes or we fill our spaces in the study.

If you are interested in participating in this clinical trial, please contact Thierry Beths.

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