Manuel was awarded a fellowship in translational research at Penns’s Institute of Translational Medicine and Therapeutics (ITMAT) where he examined the effects of hypothermia and resuscitation from cardiac arrest on microcirculation, which eventually lead to a Masters degree in translational research (MTR). In addition to his clinical and teaching activity in the Penn’s intensive care unit and anesthesia service, Manuel has been a co-investigator at Penn’s Center for Resuscitation Science since 2006 focusing on novel emergency cardiopulmonary bypass based strategies to optimise survival from prolonged cardiac arrest, on therapeutic mild hypothermia after cardiac arrest, post-resuscitation disease and microcirculatory dysfunction.

Manuel is the co-chair of the Reassessment Campaign on Veterinary Resuscitation (RECOVER), that led to evidence and consensus based clinical guidelines on veterinary CPR and is the basis for CPR training and clinical research initiatives. He is also a member of the ACVECC scientific committee.

Manuel and his wife Elise live in Melbourne with their daughters Milena and Lola.